Pancreatic β-Cells


    2023
  1. K(ATP) Channel Activity and Slow Oscillations in Pancreatic Beta Cells are Regulated by Mitochondrial ATP Production
    Jeremias Corradi, Benjamine Thompson, Patrick A. Fletcher, Richard Bertram, Arthur S. Sherman, Leslie S. Satin
    Journal of Physiology, 601:5655-5667 (2023).

  2. The Pancreatic Beta Cell: Biology and Mathematics Advance Together
    Arthur S. Sherman, Patrick A. Fletcher, Richard Bertram, Leslie S. Satin
    SIAM News, vol. 56, num. 9, pages 1 and 4 (2023).

  3. Deconstructing the Integrated Oscillator Model for Pancreatic β-Cells
    Richard Bertram, Isabella Marinelli, Patrick A. Fletcher, Leslie S. Satin, Arthur S. Sherman
    Mathematical Biosciences, 365:109085, (2023).

  4. Calcium Release or Calcium Entry, That is the Question: What Governs Calcium Oscillations in Pancreatic β-Cells?
    Patrick A. Fletcher, Ben Thompson, Chanté Liu, Richard Bertram, Leslie S. Satin, Arthur S. Sherman
    American Journal of Physiology, 324:E477-E487, (2023).

    5. 2022
  5. Coordination of Pancreatic Islet Rhythmic Activity by Delayed Negative Feedback
    N. Bruce, I.-A. Wei, W. Leng, Y. Oh, Y.-C. Chiu, M. G. Roper, R. Bertram
    American Journal of Physiology, 323:E492-E502, (2002).

  6. Pulsatile Basal Insulin Secretion is Driven by Glycolytic Oscillations
    Patrick A. Fletcher, Isabella Marinelli, Richard Bertram, Leslie S. Satin, Arthur S. Sherman
    Physiology, 37, doi:10.1152/physiol.00044.2021, (July 2022).

  7. Oscillations in K(ATP) Conductance Drive Slow Calcium Oscillations in Pancreatic β-Cells
    Isabella Marinelli, Benjamin M. Thompson, Vishal S. Parekh, Patrick A. Fletcher, Luca Gerardo-Giorda, Arthur S. Sherman, Leslie S. Satin, Richard Bertram
    Biophysical Journal, 121:1449-1464, (2022).

  8. Slow Oscillations Persist in Pancreatic Beta Cells Lacking Phosphofructokinase M
    Isabella Marinelli, Vishal Parekh, Patrick Fletcher, Benjamin Thompson, Jinhua Ren, Xiaoping Tang, Thomas L. Saunders, Joon Ha, Arthur Sherman, Richard Bertram, Leslie S. Satin
    Biophysical Journal, 121:692-704, (2022).

    9. 2021
  9. Symbiosis of Electrical and Metabolic Oscillations in Pancreatic β-Cells
    Isabella Marinelli, Patrick A. Fletcher, Arthur S. Sherman, Leslie S. Satin, Richard Bertram
    Frontiers in Physiology, 12:781581, (2021).

    10. 2020
  10. Phantom Bursting May Underlie Electrical Bursting in Single Pancreatic β-Cells
    Mehran Fazli, Theodore Vo, Richard Bertram
    Journal of Theoretical Biology, 501:110346, (2020).

  11. Chronic Stimulation Induces Adaptive Potassium Channel Activity That Restores Calcium Oscillations in Pancreatic Islets in vitro
    Nathan L. Law, Isabella Marinelli, Richard Bertram, Kathryn L. Corbin, Cara Schildmeyer, Craig S. Nunemaker
    American Journal of Physiology, 318:E554-E563, (2020).

    12. 2019
  12. Synchronization of Pancreatic Islets by Periodic or Non-Periodic Muscarinic Agonist Pulse Trains
    Joel E. Adablah, Ryan Vinson, Michael G. Roper, Richard Bertram
    PLoS ONE, 14(2):e0211832, (2019).

    13. 2018
  13. Fast-Slow Analysis of the Integrated Oscillator Model for Pancreatic β-Cells
    Joseph P. McKenna and Richard Bertram
    Journal of Theoretical Biology, 457:152-162, (2018).

  14. Transitions Between Bursting Modes in the Integrated Oscillator Model for Pancreatic β-Cells
    Isabella Marinelli, Theodore Vo, Luca Gerardo-Giorda, Richard Bertram
    Journal of Theoretical Biology, 454:310-319, (2018).

  15. Closing in on the Mechanisms of Pulsatile Insulin Secretion
    Richard Bertram, Leslie S. Satin, Arthur S. Sherman
    Diabetes, 67:351-359, (2018).

    16. 2017
  16. Upregulation of an Inward Rectifying K+ Channel Can Rescue Slow Ca2+ Oscillations in K(ATP) Channel Deficient Pancreatic Islets
    Vehpi Yildirim, Suryakiran Vadrevu, Benjamin Thompson, Leslie S. Satin, Richard Bertram
    PLoS Computational Biology, 13(7):e1005686, (2017).

  17. Calcium Oscillation Frequency-Sensitive Gene Regulation and Homeostatic Compensation in Pancreatic β-Cells
    Vehpi Yildirim, Richard Bertram
    Bulletin of Mathematical Biology, 79:1295-1324, (2017).

    18. 2016
  18. Phase Analysis of Metabolic Oscillations and Membrane Potential in Pancreatic Islet β-Cells
    Matthew J. Merrins, Chetan Poudel, Joseph P. McKenna, Joon Ha, Arthur Sherman, Richard Bertram, Leslie S. Satin
    Biophysical Journal, 110:691-699, (2016).

  19. Ca2+ Effects on ATP Production and Consumption Have Regulatory Roles on Oscillatory Islet Activity
    Joseph P. McKenna, Joon Ha, Matthew J. Merrins, Leslie S. Satin, Arthur Sherman, Richard Bertram
    Biophysical Journal, 110:733-742, (2016).

  20. Glucose Oscillations Can Activate an Endogenous Oscillator in Pancreatic Islets
    Joseph P. McKenna, Raghuram Dhumpa, Nikita Mukhitov, Michael G. Roper, Richard Bertram
    PLoS Computational Biology, 12(10):e1005143, (2016).
    21. Supporting Information

  21. Dual Detection System for Simultaneous Measurement of Intracellular Fluorescent Markers and Cellular Secretion
    Lian Yi, Basel Bandak, Xue Wang, Richard Bertram, Michael G. Roper
    Analytical Chemistry, 88:10368-10373, (2016).
    22. Supporting Information
    2015
  22. Modeling of Glucose-Induced cAMP Oscillations in Pancreatic β Cells: cAMP Rocks when Metabolism Rolls
    Bradford E. Peercy, Arthur S. Sherman, Richard Bertram
    Biophysical Journal, 109:439-449, (2015).

    23. 2014
  23. Negative Feedback Synchronizes Islets of Langerhans
    Raghuram Dhumpa, Tuan M. Truong, Xue Wang, Richard Bertram, Michael G. Roper
    Biophysical Journal, 106:2275-2282, (2014).

  24. Calcium and Metabolic Oscillations in Pancreatic Islets: Who's Driving the Bus?
    Margaret Watts, Bernard Fendler, Matthew J. Merrins, Leslie S. Satin, Richard Bertram, Arthur Sherman
    SIAM Journal on Applied Dynamical Systems, 13:683-703, (2014).
    Supplemental Material

    25. 2013
  25. Slow Oscillations of KATP Conductance in Mouse Pancreatic Islets Provide Support for Electrical Bursting Driven by Metabolic Oscillations
    Jianhua Ren, Arthur Sherman, Richard Bertram, Paulette B. Goforth, Craig S. Nunemaker, Christopher D. Waters, Leslie S. Satin
    American Journal of Physiology, 305:E805-E817, (2013).

  26. Electrical, Calcium, and Metabolic Oscillations in Pancreatic Islets.
    Richard Bertram, Arthur Sherman, Leslie S. Satin
    In The Islets of Langerhans, 2nd edition, (Ed.) Md. Shahidul Islam, Advances in Experimental Medicine and Biology, Springer, (2013).

    27. 2012
  27. Phosphofructo-2-Kinase/Fructose-2,6-Bisphosphatase Modulates Oscillations of Pancreatic Islet Metabolism
    Matthew J. Merrins, Richard Bertram, Arthur Sherman, Leslie S. Satin
    PLoS One, 7(4):e34036, doi:10.1371/journal.pone.0034036, (2012).

    28. 2011
  28. Mathematical Modeling Demonstrates How Multiple Slow Processes Can Provide Adjustable Control of Islet Bursting
    Margaret Watts, Joel Tabak, Richard Bertram
    Islets, 3:320-326, (2011).

  29. Synchronization of Mouse Islets of Langerhans by Glucose Waveforms
    Xinyu Zhang, Arij Daou, Tuan M. Truong, Richard Bertram, Michael G. Roper
    American Journal of Physiology, 301:E742-E747, (2011).

    30. 2010
  30. Microfluidic System for Generation of Sinusoidal Glucose Waveforms for Entrainment of Islets of Langerhans
    Xinyu Zhang, Alix Grimley, Richard Bertram, Michael G. Roper
    Analytical Chemistry, 82:6704-6711, (2010).

  31. Metabolic Oscillations in Pancreatic Islets Depend on the Intracellular Calcium Level but Not Calcium Oscillations
    Matthew J. Merrins, Bernard Fendler, Min Zhang, Arthur Sherman, Richard Bertram, Leslie S. Satin
    Biophysical Journal, 99:76-84, (2010).

  32. Electrical Bursting, Calcium Oscillations, and Synchronization of Pancreatic Islets
    Richard Bertram, Arthur Sherman, Leslie S. Satin
    In The Islets of Langerhans, (Ed.) Md. Shahidul Islam, Advances in Experimental Medicine and Biology, vol. 654, Springer, pp. 261-279, (2010).

    33. 2009
  33. Using Phase Relations to Identify Potential Mechanisms for Metabolic Oscillations in Isolated β-Cell Mitochondria
    Richard Bertram, Paula Budu-Grajdeanu, M. Saleet Jafri
    Islets, 2:87-94, (2009).

  34. Synchronization of Pancreatic Islet Oscillations by Intrapancreatic Ganglia: A Modeling Study
    Bernard Fendler, Min Zhang, Leslie Satin, and Richard Bertram
    Biophysical Journal, 97:722-729, (2009).

    35. 2008
  35. Long Lasting Synchronization of Calcium Oscillations by Cholinergic Stimulation in Isolated Pancreatic Islets
    Min Zhang, Bernard Fendler, Bradford Peercy, Pranay Goel, Richard Bertram, Arthur Sherman, and Leslie Satin
    Biophysical Journal, 95:4676-4688, (2008).

  36. A Mathematical Study of the Differential Effects of Two SERCA Isoforms on Calcium Oscillations in Pancreatic Islets
    Richard Bertram and Rudy C. Arceo II
    Bulletin of Mathematical Biology, 70:1251-1271, (2008).

    37. 2007
  37. Metabolic and Electrical Oscillations: Partners in Controlling Pulsatile Insulin Secretion
    Richard Bertram, Arthur Sherman, Leslie S. Satin
    American Journal of Physiology,293:E890-E900, (2007).

  38. Interaction of Glycolysis and Mitochondrial Respiration in Metabolic Oscillations of Pancreatic Islets
    Richard Bertram, Leslie S. Satin, Morten G. Pedersen, Dan S. Luciani, Arthur Sherman
    Biophysical Journal 92:1544-1555, (2007).

    39. 2006
  39. A Simplified Model for Mitochondrial ATP Production
    Richard Bertram, Morten G. Pedersen, Dan S. Luciani, Arthur Sherman
    Journal of Theoretical Biology, 243:575-586, (2006).

  40. Glucose Modulates Calcium Oscillations in Pancreatic Islets via Ionic and Glycolytic Mechanisms
    Craig S. Nunemaker, Richard Bertram, Arthur Sherman, Krasimira Tsaneva-Atanasova, Camille R. Daniel, Leslie S. Satin
    Biophysical Journal, 91:2082-2096, (2006).

  41. Diffusion of Calcium and Metabolites in Pancreatic Islets: Killing Oscillations with a Pitchfork
    Krasimira Tsaneva-Atanasova, Charles L. Zimliki, Richard Bertram, Arthur Sherman
    Biophysical Journal 90:3434-3446, (2006).

    42. 2005
  42. Individual Mice Can Be Distinguished by the Period of Their Islet Calcium Oscillations: Is There an Intrinsic Islet Period That Is Imprinted In Vivo?
    Craig S. Nunemaker, Min Zhang, D. H. Wasserman, O. P. McGuinness, A. C. Powers, Richard Bertram, Arthur Sherman, Leslie S. Satin
    Diabetes, 54:3517-3522, (2005).

  43. Integrative Modeling of the Pancreatic β-Cell
    Arthur Sherman and Richard Bertram
    In Wiley Interscience Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics, part 3, Proteomics
    (Ed.) M. Dunn, Section 3.8, Systems Biology, (Ed.) R. L. Winslow, John Wiley and Sons, Ltd., ISBN: 0-470-84974-6, (2005).

  44. Intra- and Inter-Islet Synchronization of Metabolically Driven Insulin Secretion
    Morten G. Pedersen, Richard Bertram, Arthur Sherman
    Biophysical Journal, 89:107-119, (2005).

    45. 2004
  45. Filtering of Calcium Transients by the Endoplasmic Reticulum in Pancreatic β-Cells
    Richard Bertram and Arthur Sherman
    Biophysical Journal, 87:3775-3785, (2004).

  46. Calcium and Glycolysis Mediate Multiple Bursting Modes in Pancreatic Islets
    Richard Bertram, Leslie S. Satin, Min Zhang, Paul Smolen, Arthur Sherman
    Biophysical Journal, 87:3074-3087, (2004).

  47. A Calcium-Based Phantom Bursting Model for Pancreatic Islets
    R. Bertram and A. Sherman
    Bulletin of Mathematical Biology, 66:1313-1344, (2004).

  48. Complex Bursting in Pancreatic Islets: A Potential Glycolytic Mechanism
    Keola Wierschem and Richard Bertram
    Journal of Theoretical Biology, 228:513-521, (2004).

    49. 2003
  49. The Calcium Dynamics of Isolated Mouse β-Cells and Islets: Implications for Mathematical Models
    Min Zhang, Paula Goforth, Richard Bertram, Arthur Sherman, Leslie S. Satin
    Biophysical Journal, 84:2852-2870, (2003).

    50. 2002
  50. Phantom Bursting in Pancreatic Islets: A Potential Role for Insulin Feedback
    Richard Bertram, Keola Wierschem, Min Zhang, Paula Goforth, Arthur Sherman, Leslie S. Satin
    In Recent Research Developments in Biophysics
    (Ed.) S. G. Pandalai, Transworld Research Network Publishers, 1:31-51, (2002).

  51. Calcium-Activated Potassium Channels of Mouse β-Cells are Controlled by Both Store and Cytoplasmic Calcium: Experimental and Theoretical Studies
    Paula B. Goforth, Richard Bertram, Faruk A. Khan, Min Zhang, Arthur Sherman, Leslie S. Satin
    Journal of General Physiology, 120:307-322, (2002).

    52. 2000
  52. The Phantom Burster Model for Pancreatic β-Cells
    Richard Bertram, Joseph Previte, Arthur Sherman, Tracie A. Kinard, and Leslie S. Satin
    Biophysical Journal, 79:2880-2892, (2000).

  53. Dynamical Complexity and Temporal Plasticity in Pancreatic β-Cells
    Richard Bertram and Arthur Sherman
    Journal of Biosciences, 25:197-209, (2000).

    54. 1998
  54. Glucose Diffusion in Pancreatic Islets of Langerhans
    Richard Bertram and Mark Pernarowski
    Biophysical Journal, 74:1722-1731, (1998).

    55. 1997
  55. Evidence That Calcium Release-Activated Current Mediates the Biphasic Electrical Activity of Mouse Pancreatic β-Cells
    David Mears, Norman F. Sheppard, Illani Atwater, Eduardo Rojas, Richard Bertram, Arthur Sherman Journal of Membrane Biology, 155:47-60, (1997).

    56. 1995
  56. A Role for Calcium Release-Activated Current (CRAC) in Cholinergic Modulation of Electrical Activity in Pancreatic β-Cells
    Richard Bertram, Paul Smolen, Arthur Sherman, David Mears, Illani Atwater, Franz Martin, Bernat Soria
    Biophysical Journal, 68:2323-2332, (1995).