Radiation hybrid mapping is a somatic cell technique for ordering
markers along a chromosome, and estimating the physical distances
between them. It has several advantages over alternative mapping
techniques, especially for intermediate scales maps. The present
biological techniques are capable of handling hundreds of markers
along a chromosome. With the advent of these techniques, analyzing
the experimental data is becoming a challenging and demanding
computational task. Sophisticated statistical methods are already
employed in analyzing experimental results, but their performance
for large numbers of markers has not been fully demonstrated. |
The goal of this interdisciplinary research is to explore alternative
algorithmic approaches to the analysis of radiation hybrid experiments.
We hope that successful algorithms will also have an impact on
the design of future RH experiments. We plan to develop algorithms
and test them, both on simulated data, then on real biological
data. |
