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SANDRINE DUDOIT |
Statistical Analysis of Gene Expression Data from DNA Micro-Array Experiments |
Keywords: DNA microarrays, gene expression and regulation, cancer,
moltivariate analysis, biplots, principal component analysis, clvstering
algorithms, classification trees |
My proposed postdoctoral research is the development of
novel statistical methods for the design and analysis of gene expression
experiments using DNA microarrays. The statistical questions I wish to
explore fall within the broad field of multivariate analysis and deal with,
finding efficient and intuitive ways of representing the rich and complex
data provided by microarrays, identifying sets of co-regulated genes for
different biological processes, and using gene expression patterns as diagnostic
tools in cancer research. Initially, existing statistical methods such
as principal components, block clustering and classification trees will
be investigated. Novel methods in multivariate analysis will also be developed
in order to fully exploit the potential of microarrays and to elucidate
features of pathways of co-regulated genes. |
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