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LAURIE HEYER |
A New Metric for the Construction of Phylogenetic Trees |
Keywords: alignment, RNA secondary str~bcture, phylogenetic
tree, RNA sequences |
The construction of phylogenetic trees is a central problem
in computational biology. One approach to this problem is distance based,
where the distance between two molecular sequences is defined by their
optimal global alignment. I propose investigating a new definition of distance
between RNA sequences that incorporates secondary structure as well as
the primary ribonucleotide information. The basis for this new metric is
the recently published FOLDALIGN program. |
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