A pseudoknot in mouse mammary tumor virus RNA that is required for frameshifting during translation of the viral RNA. This programmed minus-one frameshift is responsible for the synthesis of essential viral enzymes (reverse transcriptase, integrase and protease). Her structural work was reported in J. Mol. Biol. (Ref. 2), and as part of a review she wrote for FASEB J. (Ref. 3). She is co-author of a study of the functional effects of mutations in the wild-type viral pseudoknot published in EMBO J. (Ref. 1), and a summary paper on pseudoknots recently submitted to J. Mol. Biol. (Ref. 6). She also contributed to a methods paper on isotopic labeling of RNA oligonucleotides for NMR studies
in Nucleic Acids Res. (Ref, 4). Her Ph.D. thesis, ìStructure and Function of RNA Pseudoknots in Retroviral Frameshifting,î was submitted in December 1994. She then joined the research group of Professor Harry Noller, Department of Biology, University of California, Santa Cruz as an NIH postdoctoral fellow. Her postdocotoral research topic is the interaction of a frameshifting pseudoknot in a messenger RNA with the ribosomal RNA in a ribosome. |
