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NATHAN SREBO |
Mapping Disease Genes by Genetic Diversity |
Our goal is to to locate chromosome regions containing a disease gene
by whole-genome genotyping of unrelated affected individuals in a population
that underwent a recent population bottleneck. We propose doing so by searching
for chromosome regions with a low diversity ó i.e., such that many affected
individuals carry the same genetic region. |
In this work, we devised statistics to measure the genetic diversity
of a chromosome region, and analyze the effectiveness of these statistics
in distinguishing between regions containing an effecting disease gene
and regions which are of randomly low diversity. Specifically, we calculated
the required number of individuals we will need to genotype, as a function
of the population history characteristics, the frequency of the disease
and the relative risk of the gene. |
We further analyzed the needed SNP map density, and the tradeoff between
this density and the required number of genotyped individuals. We show
that in the case of sparse SNP maps, with only a few SNP markers in a non-recombined
region, different statistics should be used. |
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