Department of Mathematics

The Florida State University

This Week in Mathematics

27 - 31 March 2000

Monday: 27 March 2000

Annual Honors Day, 4:00pm, 102 Love Building

Goodner Teaching Assistant Awards

Timothy A. Cross, National High Magnetic Field Laboratory

Three Dimensional Protein Structures: Mathematical and Technical Challenges

Pi Mu Epsilon Induction of New Members Florida Beta Chapter

Reception following program in 204B Love

Tuesday: 28 March 2000

Structural Biology/Biochemistry Seminar, 11:15 a.m., 555 IMB

John Caban/Elena Falkovskaia, Florida State University

[ topic to be announced ]

Moduli Spaces Seminar, 2:00 p.m., 104 Love Building

Paolo Aluffi, Florida State University

Hilbert Schemes IX

Math. of Protein Structure & NMR Seminar, 2:30 p.m., A336 NHMFL

Jeffrey Denny, Florida State University

[ to be anounced ]

Applied Topology Seminar, 3:35 p.m., 104 Love Building

Mariel Vazquez, Florida State University

The Topology of Xer Recombination

Financial Mathematics Seminar, 3:45 p.m., Rm 109, College of Business

Pamela Coats, Finance, Florida State University

The Practice of Corporate Financial Modeling and Forecasting

Wednesday: 29 March 2000

Graduate Student Seminar, 11:15 a.m., 204B Love Building

Steve Pennington, Florida State University

[ topic to be announced ]

(Real) Analysis Seminar, 1:25 p.m., 204B Love Building

Denise Szecsei, Florida State University

A Convolution Property of some Measures with Self-Similar Fractal Support

Complex/Symbolic Seminar, 3:35 p.m., 102 Love Building

Mika Seppälä, Florida State University

Teichmuller's Extremal Mapping Theorem

Thursday: 30 March 2000

Algebraic Curves Seminar, 2:00 p.m., 104 Love Building

Eric Klassen, Florida State University

Embeddings in Projective Space II

QUANTUM! Seminar, 3:35 p.m., 104 Love Building

Phil Bowers, Florida State University

Angular Momentum Operators, Part IV: Spin and Addition Rules

Financial Mathematics Seminar, 3:45 p.m., Rm 109, College of Business

[ see Financial Mathematics Seminar 3/28/2000 ]

Friday: 31 March 2000

Colloquium Coffee, 3:00 p.m., 204 Love Building
Colloquium, 3:30 p.m., 101 Love Building

Curt McMullen, Harvard University

Real and Complex Dynamics: From [0,1] to K3 Surfaces

Joint Applied Mathematics & Scientific Computing Seminar, 4:30 p.m., 200 Love Building

Chris Homescu, Florida State University

Optimal Control of Karman Vortex Street

Seminars and colloquia at "that other" university [a.k.a. the University of Florida]

Coming Attractions

Tuesday: 4 April 2000

Structural Biology/Biochemistry Seminar, 11:15 a.m., 555 IMB

Gijs J.L. Wuite, Department of Physics and Department of Molecular and Cell Biology, University of California

Single Molecule Studies of Replication and Exonucleolysis by T7 DNA Polymerase Under Various Template Tensions

The DNA polymerase of bacteriophage T7 (T7 DNAp) is a member of the pol I family of polymerases and exists as a 1:1 complex of T7 gene 5 protein and E. coli thioredoxin. It can catalyze replication in vitro at rates up to 300 bases s-1 and has a 3' ® 5' exonuclease activity centered at a separate active site. X-ray structures of the complex of T7 DNAp with DNA and incoming dideoxy nucleotide have revealed a "right hand" shape common to most polymerases, where the thumb and fingers sub domains wrap around a cleft in the palm that accommodates the DNA. Comparison of polymerase crystal structures with and without the DNA and nucleotide suggests that DNAp flickers between an open-fingers state in which the active site can sample nucleotides and the DNA primer-template slides into position for the next catalytic cycle, and a closed-fingers state in which the nucleotide incorporation takes place. This conformational change is likely to be the step which checks for misincorporation, and that previously had been identified in kinetic studies as the rate limiting step of the catalytic cycle (Fig. 1a). Here we report the effect of mechanical force on T7 DNAp and, indirectly, on this step. Replication by individual T7 DNAp molecules was followed in time under various template tensions, using laser tweezers. Force-velocity curves reveal that template tensions below 6 piconewtons (pN) accelerate replication, whereas higher tensions slow it down, stalling the motor at 34 ± 8 pN. Analysis of the force-velocity curves indicates that T7 DNAp organizes two template bases in the polymerase active site, one of which is released at the end of the catalytic cycle. We identify the entropic and mechanical contributions to the work done by the enzyme during replication under tension, and report a force-induced 100-fold increase in exonucleolytic activity above 40 pN.

Financial Mathematics Seminar, 3:40 p.m., 200 Love Building

Patrick F. Maroney, Risk Management & Insurance, Florida State University

(A discussion of professional standards and ethics.)

Wednesday: 5 April 2000

No Graduate Student Seminar, 11:15 a.m., 204B Love Building

Thursday: 6 April 2000

Structural Biology/Biochemistry Seminar, 11:15 a.m., 555 IMB

Harry Noller, University of California at Santa Cruz

[ topic to be announced ]

Financial Mathematics Seminar, 3:40 p.m., 200 Love Building

[ see Financial Mathematics Seminar 4/4/2000 ]

QUANTUM! Seminar, 3:35 p.m., 104 Love Building

Phil Bowers, Florida State University

Quantum Mixtures and Tensor Products

Friday: 7 April 2000

Colloquium Coffee, 3:00 p.m., 204 Love Building
Colloquium, 3:30 p.m., 101 Love Building

Fred Gehring, University of Michigan

[ topic to be announced ]

Tuesday: 11 April 2000

Structural Biology/Biochemistry Seminar, 11:15 a.m., 555 IMB

Wayne Hubbell, University of California at Los Angeles

[ topic to be announced ]

Wednesday: 12 April 2000

Graduate Student Seminar, 11:15 a.m., 204B Love Building

[ speaker to be announced ]

[ topic to be announced ]

Thursday: 13 April 2000

QUANTUM! Seminar, 3:35 p.m., 104 Love Building

Phil Bowers, Florida State University

Einstein-Podolsky-Rosen (EPR) Paradoxes and Bell's Inequality

Friday: 14 April 2000

Colloquium Coffee, 3:00 p.m., 204 Love Building
Colloquium, 3:30 p.m., 101 Love Building

Slava Matveev, SUNY at Stony Brook

[ topic to be announced ]

Tuesday: 18 April 2000

Structural Biology/Biochemistry Seminar, 11:15 a.m., 555 IMB

Dan Adamak/Alex Soares, Florida State University

[ topic to be announced ]

Thursday: 20 April 2000

QUANTUM! Seminar, 3:35 p.m., 104 Love Building

Phil Bowers, Florida State University

Ensembles and Density Operators

Friday: 21 April 2000

Colloquium Coffee, 3:00 p.m., 204 Love Building
Colloquium, 3:30 p.m., 101 Love Building

Markus Rost, Institute for Advanced Study

[ topic to be announced ]

Thursday: 27 April 2000

QUANTUM! Seminar, 3:35 p.m., 104 Love Building

Phil Bowers, Florida State University

Quantum Probability and Quantum Logic

Friday: 28 April 2000

Colloquium Coffee, 3:00 p.m., 204 Love Building
Colloquium, 3:30 p.m., 101 Love Building

Ilia Binder, Harvard University

[ topic to be announced ]

April [ day to be announced ]: [ date to be announced ]

QUANTUM! Seminar, 3:35 p.m., 104 Love Building

Phil Bowers, Florida State University

Algebraic QM--C* Algebras

Financial Mathematics Seminar, 3:40 p.m., 200 Love Building

Paul Beaumont, Economics, Florida State University

Option Pricing with GARCH Models

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