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Department of Mathematics

The Florida State University

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This Week in Mathematics

27 - 31 March 2000

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Monday: 27 March 2000

* Annual Honors Day, 4:00pm, 102 Love Building
Goodner Teaching Assistant Awards
Timothy A. Cross, National High Magnetic Field Laboratory
Three Dimensional Protein Structures: Mathematical and Technical Challenges
Pi Mu Epsilon Induction of New Members Florida Beta Chapter
Reception following program in 204B Love

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Tuesday: 28 March 2000

* Structural Biology/Biochemistry Seminar, 11:15 a.m., 555 IMB
John Caban/Elena Falkovskaia, Florida State University
[ topic to be announced ]

* Moduli Spaces Seminar, 2:00 p.m., 104 Love Building
Paolo Aluffi, Florida State University
Hilbert Schemes IX

* Math. of Protein Structure & NMR Seminar, 2:30 p.m., A336 NHMFL
Jeffrey Denny, Florida State University
[ to be anounced ]

* Applied Topology Seminar, 3:35 p.m., 104 Love Building
Mariel Vazquez, Florida State University
The Topology of Xer Recombination

* Financial Mathematics Seminar, 3:45 p.m., Rm 109, College of Business
Pamela Coats, Finance, Florida State University
The Practice of Corporate Financial Modeling and Forecasting

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Wednesday: 29 March 2000

* Graduate Student Seminar, 11:15 a.m., 204B Love Building
Steve Pennington, Florida State University
[ topic to be announced ]

* (Real) Analysis Seminar, 1:25 p.m., 204B Love Building
Denise Szecsei, Florida State University
A Convolution Property of some Measures with Self-Similar Fractal Support

* Complex/Symbolic Seminar, 3:35 p.m., 102 Love Building
Mika Seppälä, Florida State University
Teichmuller's Extremal Mapping Theorem

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Thursday: 30 March 2000

* Algebraic Curves Seminar, 2:00 p.m., 104 Love Building
Eric Klassen, Florida State University
Embeddings in Projective Space II

* QUANTUM! Seminar, 3:35 p.m., 104 Love Building
Phil Bowers, Florida State University
Angular Momentum Operators, Part IV: Spin and Addition Rules

* Financial Mathematics Seminar, 3:45 p.m., Rm 109, College of Business
[ see Financial Mathematics Seminar 3/28/2000 ]

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Friday: 31 March 2000

* Colloquium Coffee, 3:00 p.m., 204 Love Building
* Colloquium, 3:30 p.m., 101 Love Building
Curt McMullen, Harvard University
Real and Complex Dynamics: From [0,1] to K3 Surfaces

* Joint Applied Mathematics & Scientific Computing Seminar, 4:30 p.m., 200 Love Building
Chris Homescu, Florida State University
Optimal Control of Karman Vortex Street

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* Seminars and colloquia at "that other" university [a.k.a. the University of Florida]
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Coming Attractions

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Tuesday: 4 April 2000

* Structural Biology/Biochemistry Seminar, 11:15 a.m., 555 IMB
Gijs J.L. Wuite, Department of Physics and Department of Molecular and Cell Biology, University of California
Single Molecule Studies of Replication and Exonucleolysis by T7 DNA Polymerase Under Various Template Tensions
The DNA polymerase of bacteriophage T7 (T7 DNAp) is a member of the pol I family of polymerases and exists as a 1:1 complex of T7 gene 5 protein and E. coli thioredoxin. It can catalyze replication in vitro at rates up to 300 bases s-1 and has a 3' ® 5' exonuclease activity centered at a separate active site. X-ray structures of the complex of T7 DNAp with DNA and incoming dideoxy nucleotide have revealed a "right hand" shape common to most polymerases, where the thumb and fingers sub domains wrap around a cleft in the palm that accommodates the DNA. Comparison of polymerase crystal structures with and without the DNA and nucleotide suggests that DNAp flickers between an open-fingers state in which the active site can sample nucleotides and the DNA primer-template slides into position for the next catalytic cycle, and a closed-fingers state in which the nucleotide incorporation takes place. This conformational change is likely to be the step which checks for misincorporation, and that previously had been identified in kinetic studies as the rate limiting step of the catalytic cycle (Fig. 1a). Here we report the effect of mechanical force on T7 DNAp and, indirectly, on this step. Replication by individual T7 DNAp molecules was followed in time under various template tensions, using laser tweezers. Force-velocity curves reveal that template tensions below 6 piconewtons (pN) accelerate replication, whereas higher tensions slow it down, stalling the motor at 34 ± 8 pN. Analysis of the force-velocity curves indicates that T7 DNAp organizes two template bases in the polymerase active site, one of which is released at the end of the catalytic cycle. We identify the entropic and mechanical contributions to the work done by the enzyme during replication under tension, and report a force-induced 100-fold increase in exonucleolytic activity above 40 pN.

* Financial Mathematics Seminar, 3:40 p.m., 200 Love Building
Patrick F. Maroney, Risk Management & Insurance, Florida State University
(A discussion of professional standards and ethics.)

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Wednesday: 5 April 2000

* No Graduate Student Seminar, 11:15 a.m., 204B Love Building

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Thursday: 6 April 2000

* Structural Biology/Biochemistry Seminar, 11:15 a.m., 555 IMB
Harry Noller, University of California at Santa Cruz
[ topic to be announced ]

* Financial Mathematics Seminar, 3:40 p.m., 200 Love Building
[ see Financial Mathematics Seminar 4/4/2000 ]

* QUANTUM! Seminar, 3:35 p.m., 104 Love Building
Phil Bowers, Florida State University
Quantum Mixtures and Tensor Products

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Friday: 7 April 2000

* Colloquium Coffee, 3:00 p.m., 204 Love Building
* Colloquium, 3:30 p.m., 101 Love Building
Fred Gehring, University of Michigan
[ topic to be announced ]

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Tuesday: 11 April 2000

* Structural Biology/Biochemistry Seminar, 11:15 a.m., 555 IMB
Wayne Hubbell, University of California at Los Angeles
[ topic to be announced ]

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Wednesday: 12 April 2000

* Graduate Student Seminar, 11:15 a.m., 204B Love Building
[ speaker to be announced ]
[ topic to be announced ]

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Thursday: 13 April 2000

* QUANTUM! Seminar, 3:35 p.m., 104 Love Building
Phil Bowers, Florida State University
Einstein-Podolsky-Rosen (EPR) Paradoxes and Bell's Inequality

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Friday: 14 April 2000

* Colloquium Coffee, 3:00 p.m., 204 Love Building
* Colloquium, 3:30 p.m., 101 Love Building
Slava Matveev, SUNY at Stony Brook
[ topic to be announced ]

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Tuesday: 18 April 2000

* Structural Biology/Biochemistry Seminar, 11:15 a.m., 555 IMB
Dan Adamak/Alex Soares, Florida State University
[ topic to be announced ]

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Thursday: 20 April 2000

* QUANTUM! Seminar, 3:35 p.m., 104 Love Building
Phil Bowers, Florida State University
Ensembles and Density Operators

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Friday: 21 April 2000

* Colloquium Coffee, 3:00 p.m., 204 Love Building
* Colloquium, 3:30 p.m., 101 Love Building
Markus Rost, Institute for Advanced Study
[ topic to be announced ]

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Thursday: 27 April 2000

* QUANTUM! Seminar, 3:35 p.m., 104 Love Building
Phil Bowers, Florida State University
Quantum Probability and Quantum Logic

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Friday: 28 April 2000

* Colloquium Coffee, 3:00 p.m., 204 Love Building
* Colloquium, 3:30 p.m., 101 Love Building
Ilia Binder, Harvard University
[ topic to be announced ]

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April [ day to be announced ]: [ date to be announced ]

* QUANTUM! Seminar, 3:35 p.m., 104 Love Building
Phil Bowers, Florida State University
Algebraic QM--C* Algebras

* Financial Mathematics Seminar, 3:40 p.m., 200 Love Building
Paul Beaumont, Economics, Florida State University
Option Pricing with GARCH Models

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This document is maintained by Melissa Elaine Smith / smith@math.fsu.edu

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