- Marion Bradley Brennan Professor of Mathematics, 2015-2018
- Director of Biomathematics Program, FSU, Fall 2010-present
- Professor of Biomathematics, FSU, Fall 2009-present
- Graduate Faculty Member, Molecular Biophysics Program,
FSU, Fall 2001-present
- Graduate Faculty Member, Neuroscience Program,
FSU, Summer 2005-present
- NIH R01 DK 080714: Four-year award for
"Microfluidic Devices for Determining Dynamics of Islets of Langerhans",
Mike Roper (PI), Richard Bertram, 2013-2017.
- NSF IOS 1456965: Three-year award for
"Parallel Encoding of Sequence and Structure in a Motor Memory Trace",
Frank Johnson (PI), Richard Bertram, Rick Hyson, Wei Wu, 2015-2018.
- NSF DMS 1612193: Three-year award for
"Analysis and Extension of a Model for Oscillatory Islet Activity",
Richard Bertram (PI), 2016-2019.
Current Research Interests
Activity of Pancreatic Beta-Cells
Pancreatic Beta-cells are located in islets of Langerhans in the pancreas and
are the only cells in the body that
secrete insulin, a hormone that is necessary for the uptake of glucose
by other cells. Defects in beta-cell functioning lead to diabetes, which
can result in death if not treated. The release of insulin is controlled
by many physiological variables, including the cell's electrical activity,
calcium, and nucleotide concentrations. I work in the development and
analysis of mathematical models of beta-cell activity as well as potential methods
for islet syncrhonization.
Hypothalamic Control of Hormone Secretion
The hypothalamus is the region of the brain that regulates the level and
timing of hormone release from endocrine glands. One such gland, the pituitary,
is located near the hypothalamus, and secretions from this gland regulate
secretions from other glands. For this reason, the pituitary is sometimes called
the "master gland". The hypothalamus sends both stimulatory and inhibitory
input to the pituitary, resulting in neural regulation of secretion from
gonadotrophs, somatotrophs, corticotrophs, melanotrophs, and lactotrophs.
I develop mathematical models of pituitary cells, and work with collaborators
to test model predictions and design new experiments.
Bursting Oscillations in Excitable Cells
In nerve cells, information is transmitted through electrical impulses.
Electrical impulses also cause muscles to contract and endocrine cells
to secrete hormones. Quite often, impulses are generated as high-frequency
bursts, followed by periods of quiescence. This is particularly true in
endocrine cells such as pancreatic beta-cells and pituitary cells. I am
interested both in the dynamics of bursting (a mathematical topic) and in
the mechanisms by which different cells generate periodic bursts of
impulses (a biological topic).
Neural Network Controlling Bird Songs
Song birds have a dedicated region of the brain to produce songs.
We are studying the neural mechanisms through which the song is produced in the
male zebra finch, which is a good paradigm for the learning of sequential behavior
(like reciting the alphabet). It also has some parralels with the learning of human
speach production. We study neural electrical activity, and features of the song
that is produced. We are also developing computational models for the neural
activity and connectivity that can produce the sequential behavior that results
in the stereotyped song of the male zebra finch. Here are links to videos that the
birdsong group recently made:
Team Collaboration ,
Hypothalamus and Pituitary
Neural Basis of Birdsong
Students and Collaborators
Hypothalamus and Pituitary
Workshops and Conferences
Prof. Richard Bertram
Department of Mathematics
Florida State University
Tallahassee, Fl 32306
tel.: (850)-644-7195 (math office), (850)-644-7632 (IMB office)