Graduate Faculty Member, Institute of Molecular Biophysics

Graduate Faculty Member, Program in Neuroscience

Florida State University

- Fellow of the Society for Mathematical Biology, awarded 2023 SMB Fellow Awardees
- Tam Family Professor of Mathematics, 2019-2025
- Distinguished Research Professor, awarded 2019 DRP Awardees
- Marion Bradley Brennan Professor of Mathematics, 2015-2018
- Director of Biomathematics Program, FSU, 2010-present
- Professor of Biomathematics, FSU, 2009-present
- Graduate Faculty Member, Molecular Biophysics Program, FSU, 2001-present
- Graduate Faculty Member, Neuroscience Program, FSU, 2005-present

- NIH R01 DK 080714: Four-year award for "Microfluidic Devices for Determining Dynamics of Islets of Langerhans", Mike Roper (PI), Richard Bertram, 2022-2026.
- NSF DMS 2324962: Three-year award for "New Approaches for Interpreting Neural Responses to Behaviorally-Relevant Sensory Stimuli", Richard Bertram (PI), Tom Needham, Martin Bauer, Roberto Vincis, 2023-2026.
- Navy Medicine award N626451920001: Two-year subcontract for "Mathematical Analysis of Transcriptomic, Proteomic, and Metabolomic Biomarker Signatures in Septic Cohorts", Richard Bertram (PI), 2023-2024.

- Debuty Editor, Mathematical Biosciences (since 2013).
- Editorial Board member, Bulletin of Mathematical Biology (since 2016).
- Editorial Board member, Biophysical Journal (since 2023).
- Editorial Board member, SIAM book series on Mathematical Neuroscience (since 2023).

Slides

Notes

Course software

Pancreatic Beta-cells are located in islets of Langerhans in the pancreas and are the only cells in the body that secrete insulin, a hormone that is necessary for the uptake of glucose by other cells. Defects in beta-cell functioning lead to diabetes, which can result in death if not treated. The release of insulin is controlled by many physiological variables, including the cell's electrical activity, calcium, and nucleotide concentrations. I work in the development and analysis of mathematical models of beta-cell activity as well as potential methods for islet syncrhonization.

The hypothalamus is the region of the brain that regulates the level and timing of hormone release from endocrine glands. One such gland, the pituitary, is located near the hypothalamus, and secretions from this gland regulate secretions from other glands. For this reason, the pituitary is sometimes called the "master gland". The hypothalamus sends both stimulatory and inhibitory input to the pituitary, resulting in neural regulation of secretion from gonadotrophs, somatotrophs, corticotrophs, melanotrophs, and lactotrophs. I develop mathematical models of pituitary cells, and work with collaborators to test model predictions and design new experiments.

In nerve cells, information is transmitted through electrical impulses. Electrical impulses also cause muscles to contract and endocrine cells to secrete hormones. Quite often, impulses are generated as high-frequency bursts, followed by periods of quiescence. This is particularly true in endocrine cells such as pancreatic beta-cells and pituitary cells. I am interested both in the dynamics of bursting (a mathematical topic) and in the mechanisms by which different cells generate periodic bursts of impulses (a biological topic).

Many biological systems can be described as networks of interconnected nodes. I study these, in the context of neuroscience and gene transcription. In particular, I look at networks of interconnected pituitary cells, each of which is capable of bursting. The coupling is through gap junctions, so is electrical in nature. I also look at networks of neurons, where the coupling is through synapses and therefore chemical in nature. Finally, I am involved in the development of new approaches for studying networks of gene expression and neural spike trains.

Pancreatic Beta-Cells

Synaptic Transmission

Structural Biology

Hypothalamus and Pituitary

Neural Basis of Birdsong

Bursting Analysis

Cardiac Models

Other Topics

Hypothalamus and Pituitary

Synaptic Transmission

Pancreatic Islet

Neuron

Birdsong

Bursting Analysis

Cardiac Models

Other Topics

Prof. Richard Bertram

Department of Mathematics

Florida State University

Tallahassee, Fl 32306

tel.: (850)-644-7632 (IMB office)

e-mail:
rbertram@fsu.edu