Mathematics Colloquium
Lorena Bociu
NC State
Title: Analysis and Control in Poroelastic Systems with Applications to Biomedicineg
Date: Friday, February 13th
Place and Time: Love 101, 3:05-3:55 pm
Abstract. In biomechanics, local phenomena, such as tissue perfusion, are strictly related to the global features of the surrounding blood circulation. We propose a heterogeneous model where a local, accurate, 3D description of fluid flows through deformable porous media by means of poroelastic systems is coupled with a systemic 0D lumped model of the remainder of the circulation. This represents a multiscale strategy, which couples an initial boundary value problem to be used in a specific region with an initial value problem for the rest of the circulatory system. We present new results on wellposedness analysis, optimal control and solution methods for this nonlinear multiscale interface coupling of PDEs and ODEs. Our results have applications in biomedicine and bioengineering, including tissue perfusion, fluid flow inside cartilages and bones, and design of bioartificial organs.